Wound healing from a cellular stress response perspective
نویسندگان
چکیده
منابع مشابه
Stress and wound healing.
Over the past decade it has become clear that stress can significantly slow wound healing: stressors ranging in magnitude and duration impair healing in humans and animals. For example, in humans, the chronic stress of caregiving as well as the relatively brief stress of academic examinations impedes healing. Similarly, restraint stress slows healing in mice. The interactive effects of glucocor...
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Wound healing is a dynamic interactive process that involves a sequence of molecular and cellular events. Recent advances in cellular and molecular biology have greatly expanded our understanding of the biological process involved in wound repair and tissue regeneration. From plasma extravasation, with coagulation and platelet aggregation, to reepithelialization and remodeling of injured tissue...
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Mammalian wound healing involves the rapid synthesis and deposition of extracellular matrix (ECM) to maintain tissue integrity during repair. This process must be tightly controlled, as its deregulation may result in fibrosis, scarring, and loss of tissue function. Recent studies have uncovered an efficient and parsimonious mechanism for rendering fibrogenesis self-limiting in wound healing: in...
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The skin is the largest and heaviest organ and the most vital protective mechanism against foreign organism invasion and physical injury. It consists of two layers, the dermis and epidermis, both of which include different types of cells, including keratinocytes, melanocytes, and Langerhans and Merkel cells, as well as collagen and elastic fibers, in which fibroblasts, macrophages, mast cells, ...
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Bone marrow mesenchymal stem cells MSCs) secrete paracrine factors that may exert healing effect on the wounded tissues. This study was done to determinate the effect of MSCs or MSC-Conditioned Media MSC-CM) on the wound healing in intact mice, and under hyperglycemic condition. We established a burned wound healing mice diabetes mellitus DM) model and cultured primary bone marrow MCSs. A MSCs ...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2008
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-008-0059-8